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Differences in defense mechanisms, and the more severe characteristics of LRTIs than URTIs, may account for the increased risk of LRTIs [ 43, 44].
In addition, compromised dopaminergic transmission but also more severe characteristics such as Purkinje cell degeneration and demyelination of peripheral nerves leading to ataxia have been reported in Prnp−/− animals.
Interestingly, KO animals for the gene encoding PrPC exhibit phenotypes with impaired long-term potentiation (14– 16), abnormal circadian rhythm (17) or effects on glutamatergic transmission (18, 19) but also more severe characteristics such as Purkinje cell degeneration and demyelination of peripheral nerves leading to ataxia (11, 20).
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Compared to subjects with higher platelet density, they had more severe inflammatory characteristics.
Despite more severe illness characteristics, the magnitude of their treatment gains was equivalent or superior to that of the participants without anxiety disorders on a variety of outcome measures.
This study did not find more severe ADHD characteristics to be associated with more severe ED symptoms in women diagnosed with ED.
Our reported prevalence of RVGE might have been affected by selecting only severe GE cases with more severe disease characteristics, including longer hospital stays.
This study shows an association between increased spread of pain and prevalence of heart disease, hypertension, more severe pain characteristics (i.e., intensity, frequency and duration), problems with common daily activities and increased health care seeking.
This study shows that there is an association between increased spreading of pain and prevalence of heart disease, hypertension, more severe pain characteristics (i.e., intensity, frequency and duration), problems with common daily activities and increased health care seeking.
The 49-item CSBQ is an instrument able to measure less severe variants of ASD symptomatology and ASD related problems (such as problems in executive functioning and disruptive behavior), whereas the SCQ is designed to measure the more severe ASD characteristics.
Although this novel AMPK activation supports a role for the kinase in counteraction of oxidative stress, we demonstrate that increased AMPK activity does not simply translate to increased eNOS phosphorylation in these subjects and is therefore not sufficient to attenuate the more severe endothelial dysfunction characteristic of diabetic patients.
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