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The reason that MPA induces a lower level of Rpb1 sumoylation than UV may reflect the fact that UV induced DNA damage may cause a more severe blockage of elongating Pol II.
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Importantly, in all cases the severity of the blockage was more severe for the minor groove adducts relative to those in the major groove.
This may explain the increased occurrence of nose-bleeding, a more severe symptom than nasal crusts and blockage.
Their spectra of symptoms also overlap, although those from arterial gas embolism are generally more severe because they often arise from an infarction (blockage of blood supply and tissue death).
With the γ-OH-PdG-adducted templates, the extent of the blockage to DNA synthesis was more severe, with a major pause site detected one nucleotide prior to the lesion and another pause site opposite the lesion.
When coronary arteriography reveals a severe blockage of the left main coronary artery or proximally in one or more of the major arteries, coronary artery bypass graft surgery may be necessary.
More severe or less severe?
The more severe crashes.
Sentences are more severe.
The negativity is more severe".
Their words became more severe.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com