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However, some children experience more severe behaviour problems, known as behavior disorders.
This decrease may explain pop2-1 oversensitive phenotype in response to NaCl since a similar, but more severe, behaviour has been observed in the mutant of the Salt Overly Sensitive 1 locus [ 4].
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Less severe forms of food rationing include cutting portion sizes to more severe behaviours such as skipping meals completely [ 67, 71].
Therefore a high PCDAI score in our pediatric-onset CD patients with NOD2 variants reflects a more severe disease behaviour indicated by underweight, stricturing and penetrating behaviour.
Since AHSS demonstrates more severe springback behaviour than ordinary mild steels, it requires more efforts to meet the design specification of the stamped parts.
Similarly, in a normative sample, Silvern and colleagues [ 28] reported that, among 10 11 year-old boys, superior cognitive perspective-taking was associated with relatively more severe antisocial behaviour.
Present data have shown that CD-high-CU children exhibit relatively more severe antisocial behaviour than their CD-low-CU counterparts.
Indeed, finger-stained smokers seem to present a more severe addictive behaviour (high proportion of harmful alcohol use, early age at smoking onset, high number of cigarettes smoked per day and few cigarette breaks).
Given also that CD-high-CU children exhibited relatively more severe antisocial behaviour than their CD-low-CU counterparts, this interpretation seems difficult to reconcile with the findings of Waterman et al. [ 13], who found that affective but not cognitive perspective-taking superiorities are related to more serious patterns of antisocial behaviour in CD children.
In a further normative study challenging conceptual expectations, and suggestive of a differentiated operation of affective and cognitive perspective-taking, Silvern and colleagues [ 28] reported that, among 10 11 year-old boys, cognitive perspective-taking superiority was associated with relatively more severe antisocial behaviour.
This allele was associated with greater impairments in social interaction (P = 0.0016) and nonverbal communication (P = 0.0046), and more severe stereotyped behaviours (P = 0.00072), core features of ASDs.
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