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Some studies in mouse models of Alzheimer's disease have also found that female rodents had more severe behavioral and neurological defects than their brothers.
Per1−/− or Per2−/− mice, for example, have more severe behavioral phenotypes than Per3−/− mice.
If the ACC were the only region to activate the cognitive control network, we would expect more severe behavioral effects in these populations.
It is unclear whether lower blood lead levels are associated with more severe behavioral problems such as CD in children.
Higher sores represent more severe behavioral problems, except in the case of the Prosocial Scale, where higher scores mean better performance (strengths).
This may explain why adult Kirrel3 knockout mice have only moderate behavioral impairments and suggests that younger animals may have more severe behavioral problems.
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The male Mecp2-null model completely lacks functional Mecp2 expression, and displays a more severe gross behavioral phenotype.
A study by Catroppa et al. assessed adaptive functioning 10 years post-injury in children with early TBI and observed poorer adaptive skills for those with more severe injury and behavioral difficulties [13].
One hypothesis to explain the more severe electrophysiological and behavioral effects of the D36 mutant is illustrated in Fig. 8. AKAP5 binds both kinases (PKA and PKC) and a phosphatase (calcineurin) and we suggest that the kinase/phosphatase balance in the dendritic spine is critical in the regulation of downstream targets.
Bussing et al. [ 13] also found that children with severe asthma were 3 times more likely to demonstrate severe behavioral problems compared to children without chronic conditions.
Internalizing problems did not predominate over externalizing ones (i.e., acted-out problems, reflecting undercontrol of emotion and behavior), revealing a symptomatic nature of behavioral syndromes more severe than expected.
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