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But doctors are using a growing number of treatments for people like Mr. Nickerson, who have the more serious systemic form, also called systemic sclerosis.
Moreover, they can be used to better monitor the more serious systemic complications of SSc.
Poor glycemic control was further associated with components of metabolic syndrome including higher BMI, unfavorable lipid profile, uncontrolled blood pressure, and with markers of inflammation, malnutrition, and a more serious systemic disease.
While low serum album levels may represent malnutrition arising from uremic syndrome, they may also be a marker of comorbidities and inflammation more generally, indicative of a more serious systemic disease [ 36].
The here described work is dealing with results obtained with Bacillus cereus, an opportunistic human and insect pathogen, which is often associated with mild intestinal affections as well as more serious systemic infections in human.
In this cohort of incident end-stage renal disease patients with diabetes, poor glycemic control was independently associated with younger age, Native American race, Hispanic ethnicity, higher body mass index, and clinical risk factors including atherogenic lipoprotein profile, hypertension, inflammation, and markers indicative of malnutrition and a more serious systemic disease.
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Sometimes years intervene between the early manifestations and the more serious signs of systemic involvement, which may include difficulty in breathing or swallowing, gastrointestinal disorders, kidney malfunction, and inflammation of the heart lining, heart muscle, or sac enclosing the heart.
Arguable indications are the presence of more than one serious systemic embolic episode or one embolus with large residual vegetation [ 4].
If early diagnosis is not made and prompt treatment not given, then the disease may remain quiescent until more serious symptoms or systemic involvement develops.
You either have a localized infection at the piercing site or a more serious (potentially fatal) systemic infection.
We need more serious, more rapid and more systemic reforms than the episodic and occasionally ones we are currently experiencing.
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