Illumina wants to be more than a seller of sequencing machines.
The advantage of ORPs is the dynamic context specific error estimation and error correction, which significantly reduces sequencing error and is more robust in the face of configuration changes across sequencing machines.
It takes advantage of the rising speed and falling costs of sequencing machines.
Recalibration used read group, reported quality score, sequencing machine cycle and sequence context as covariates.
With the advent of more competitively priced next-generation sequencing machines, which can provide sequence data in a matter of hours, not days (such as Life Technologies Ion-torrentt and Illumina's Miseq), it is feasible that such approaches could be used routinely in the clinical setting.
This allows comparing across libraries for differentially expressed genes, which will become more relevant with the large number of ESTs generated by the next-generation sequencing machines.
Modern sequencing machines are capable of sequencing several genomes at the same time, more precisely the input can be a microbiome community composed of thousands of different organisms.
Makers of gene sequencing machines like Applied Biosystems continue to improve their machines.
Genomic sequences are usually determined using automatic sequencing machines.
