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Our ever more sensitive technologies turn up more and more abnormalities — cancers, clogged arteries, damaged-looking knees and backs — that aren't actually causing problems and never will.
Our ever more sensitive technologies turn up more and more abnormalities cancers, clogged arteries, damaged-looking knees and backs that aren't actually causing problems and never will.
The Obama administration defended the decision by saying that loosening restrictions on less sensitive items would free up resources to track more sensitive technologies that could fall into the wrong hands.
DRMs that are not detected by standard sequencing but detected using more sensitive technologies have been referred to as "minority" or "low-level" drug-resistant variants in the literature [1] [9].
This 'stage-dependency' may restrict cfDNA as a detection method in trials of agents for advanced disease, although more sensitive technologies may alter this in the future.
It is plausible that in the remaining patients the proportion of cfDNA is below the detection of conventional MPS methods, arguing for more sensitive technologies.
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This can not be explained by differences in the sensitivity of these technologies as the more sensitive technology should include also the antigens discovered by the less sensitive approach.
Indeed, it is new or more sensitive technology that can open up new horizons in biology.
"Every time a more sensitive technology has become available, it has opened up new diagnostics and led to advances in treatment," says Walt.
Availability of the newer and more sensitive technology to quantify the level of leukemic burden raises the issue of whether MRD should emerge as a new definition of complete response.
Massively parallel sequencing of expressed sequenced tags (also named massively parallel signature sequencing, MPSS) is a more sensitive technology in reliably detecting low expression transcripts [10] [12] and has been shown to complement current DNA microarray technologies [13].
More suggestions(15)
more sensitive technology
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more traditional technologies
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