In addition, this study indicates that for more sensitive stage-specific diagnosis or prognosis, both methylation of promoter and expression studies must be considered in the analyses in a reproducible manner.
In general, CT was more sensitive for staging of liver and lung lesions whereas PET performed significantly better in the detection of bone metastases.
Additional populations, such as those exposed to higher levels of OCs, and more sensitive life stages (i.e., embryo) should also be investigated because they may face a greater risk than juvenile turtles foraging in North Carolina waters.
RNA derived from milk cells was also slightly more sensitive to lactation stage.
Although the 2002 AJCC TNM staging system was more sensitive than the VALSG staging system for predicting survival status, we recommend using both staging systems in clinical practice.
However, these linear methods exhibit lower sensitivity to distributed defects and contact-type defects at the micro-scale (Jhang 2009; Park et al. 2015) compared to nonlinear ultrasonic methods, which are more sensitive to early-stage micro-scale defects as these defects cause nonlinear behavior of an incident wave (Zaitsev et al. 2006).
The CRP is considered a good marker of AI, being more sensitive in late stages [ 23].
Radiography remains the cornerstone of diagnosis although MRI is more sensitive in early stages of the disease.
A recent study demonstrated that TK1-ELISA is more sensitive for early-stage detection of lung cancer compared with STK1 activity assays [ 31].
Nevertheless, a need for better instruments, which are more sensitive to disease staging or changes over time, has been acknowledged by the European Medicines Agency [ 5] and recently confirmed by reviewing the outcome measures used in current clinical trials [ 8].
This test setup is used because early life stages are more sensitive than the adult life stage.
