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Our assays examined HCV spread within populations where miR-122 is stably inhibited and, thus, are likely to provide a more sensitive readout of miR-122 dependency.
Engineers have been recording information magnetically and reading it out electrically since the dawn of the computer age, but as they have endeavored to pack more and more data onto their machines, they have been forced to use smaller and fainter magnetic inscriptions and thus more and more sensitive readout devices.
Therefore, S.Tm* should provide a more sensitive readout than wt S.Tm for any effects of IL-17RA on Salmonella enterocolitis.
To confirm a direct influence of intracellular MPP+ on mitochondria, metabolic flux measurements were obtained as a more sensitive readout.
We believe that simultaneous measurements of several biomarkers with unique characteristics will provide a more sensitive readout of the temporal changes in pathological profile of IPF.
Degranulation has been shown to be a direct measure of killing by CTLs and is considered a more sensitive readout of CTL functioning.
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Their study showed that FMT provides more sensitive readouts in the pathology of the disease and that it is possible to use FMT results to predict disease development [ 30].
In fact, these mutants were able to support replication of φCr30 (as shown by cells lysis in Figure 3G), indicating that they are indeed partially functional and that the φCr30 spot assay is much more sensitive as readout, possibly because localized breaches in the capsule are sufficient to promote φCr30 infection at a high multiplicity of infection (m.o.i).o.i
Further examination of this latter group revealed that in 11 out of 14 combinations, the automatic readout was more sensitive than the manual readout in detecting neutralization (denoted as triangles above the diagonal line in Figure 5).
It is interesting to note that the 92UG024 virus, yielding relatively small plaques, was used in five of the 11 cases where automatic readout was more sensitive, suggesting that the small plaques may be more difficult to score by eye.
Other variations upon the assay have been developed, including both flow-cytometric readouts, and potentially more sensitive two-lifecycle assays (originally developed for use in immuno-epidemiological studies).
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