Developing assays with PLNPs as reporters could lead to more sensitive point-of-care tests with significantly cheaper and simpler field-portable readers.
Compared with the AGD index, NR was generally the more sensitive end point.
Time to facial muscle recovery may be a more sensitive end point.
This implies 72 hours post infection is a more sensitive time point for determination of transduction efficiency, rather than earlier timepoints.
To further evaluate the relation between PCB exposure and breast cancer risk, we studied incidence, a more sensitive end point than mortality, in an occupational cohort.
The team found reproductive behavior and success to be a more sensitive end point than fish mortality for measuring chemical contamination in urban streams.
Results for male offspring were not reported in the CD-1 mouse study (Hines et al. 2009), and experimental studies have suggested that reproductive development, but not weight gain, may be a more sensitive end point for males with respect to developmental exposures to PFAAs (Shi et al. 2007).
In contrast, findings have been inconsistent among previous epidemiologic studies that examined late pubertal milestones rather than pubertal onset (potentially a more sensitive end point) and have been limited either by small sample size, cross-sectional design, self-reported pubertal staging, or lack of an exposure biomarker.
In this context, Markey et al. (2001) reported that the VO assay was a more sensitive end point than the increase in uterine wet weight for determining the estrogenic activity of bisphenol A. This finding prompted us to evaluate the effects of 20 different rodent diets containing different concentrations of phytoestrogens on the time of VO in CD-1 mice (Thigpen et al. 2003, 2004b).
In such appearances, Mr. Bush emphasizes the job-creation capabilities of technologies like broadband without mentioning the more politically sensitive point that the same technology has made the outsourcing of American jobs possible.
