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In these terms we will have to await the development of more sensitive phenotype tests before the function of these network proteins emerges.
In contrast, the PierC1 strain showed a more sensitive phenotype than R551-3 that showed a medium resistance level.
This would suggest that the hyposensitive trait is shared between the ancestral bony vertebrate GRs and the more sensitive phenotype is derived.
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The more "connected" (in a network of dependency) the gene products are, the more sensitive the phenotype is to changes in product concentration (altering an individual's fitness) (Freeling 2009; Birchler and Veitia 2012).
In seed germination assays under ABA treatment, all the double and triple mutants of cytosolic AtACBPs showed a more sensitive germination phenotype in comparison with the wild type, suggesting that the change in the acyl-CoA pool size may have contributed to their sensitivity to ABA during seed germination.
Although the loss of Foxa3 resulted in a lean, energy inefficient and more insulin sensitive phenotype in mice older than one year old (Ma et al. 2014), it has been suggested that Foxa3 is a "hoarder" gene to facilitate lipid storage in aged animals (Ma et al. 2015).
It is also interesting to see that two biomarkers are from downstream m/z ratios, which were believed to be more sensitive to detect phenotype information than those from upstream m/z ratios [ 24].
A more sensitive and reliable phenotyping assay would be ideal to elucidate this.
All significant correlations that were found between S-phase fractions and drug resistance were inverse, that is, higher S-phase fractions were related to lower LC50 values or a more drug-sensitive phenotype.
This negative regulation of APUM5 could be connected to a more sensitive 35S-APUM5 transgenic plant phenotype under abiotic stress.
Whether Ki67 is mechanistically involved in the response to docetaxel remains to be demonstrated, but even if it is not, it may be a marker of a phenotype more sensitive to docetaxel.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com