Sentence examples for more sensitive endpoints from inspiring English sources

Standard test data are still preferred and recommended for regulatory environmental risk assessments of pharmaceuticals even though data generated by non-standard tests could improve the scientific basis of risk assessments by providing relevant and more sensitive endpoints.

However, what is now needed is a systems-level approach investigating more subtle yet potentially more significant impacts of nanomaterial exposure in agricultural systems, including the use of a range of more sensitive endpoints that can mechanistically characterize toxicity.

For PCBs, risk was first assessed at high doses in adults, but later more sensitive endpoints were detected at lower doses and in earlier life-stages.

This so-called "CLARITY-BPA" study also represents a paradigm that could easily incorporate a strategy to validate new and more sensitive endpoints into guideline studies [ 39].

Other end-points, such as oxygen transport variables, D O2, cardiac index, V O2, lactate, base deficit, and mucosal gastric pH, are all more sensitive endpoints of cellular resuscitation [ 65].

These two points underline the need to develop more sensitive endpoints better able to demonstrate the true benefit of antineoplastic treatments, particularly as targeted therapies may moderately increase response rates but also improve the quality of the response and reduce the risk of progression.

These results demonstrated that population density was a much more sensitive endpoint for population level risk assessments.

This suggests that cholinesterase inhibition is at least a 10-fold more sensitive endpoint than pup mortality for dietary exposures.

However, it should be acknowledged that immobility is a more sensitive endpoint and that mortality may in fact be caused by nanoparticle adhesion.

The tumorigenic response occurred at doses higher than those associated with effects in pigs, however cancer is considered a more sensitive endpoint if associated with a nonthreshold mechanism of action.

Focusing on earlier, potentially more sensitive biological endpoints that represent key events will facilitate the use of data directly from environmentally relevant human exposures, and/or the use of in vitro model systems using human-derived tissues or cells.