This active engagement leads to smarter questions, better learning, and a more sensitive early warning radar to coming changes.
The panel also pointed out that the WHO was slow in declaring a "public health emergency of international concern" because messages from the field about Ebola either "did not reach senior leaders or senior leaders did not recognize their significance". A more sensitive early warning system is needed.
The application of clinical pathology testing in preclinical safety assessment, and the areas of development for novel biomarker implementation within the laboratory to expand testing capability and improve its contribution to the identification of more sensitive, early signals of drug- induced target organ toxicity or pathophysiology, are discussed.
In this regard, clinical prediction algorithms and more sensitive early diagnostic techniques may assist in guiding early antifungal intervention.
BDG detection is a more sensitive, early positive test, and therefore appears useful for first-line screening.
Some have suggested that amniotic fluid insulin may be a more sensitive early predictor of GDM than amniotic fluid glucose, but neither has emerged as an early screening tool (4).
Since newly emerging biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 have been extensively validated as more sensitive early diagnostic markers for AKI than serum creatinine, the concept of subclinical AKI has recently emerged.
In this regard, given the theory of the pathogenesis of atherosclerosis [ 41], with detection of endothelial dysfunction predicting an early functional disturbance of the vessel wall and measurement of IMT functioning as an early morphological sign [ 42], our findings emphasize the likelihood that sCD146 is a more sensitive and earlier predictor of subclinical endothelial dysfunction than CIMT.
ChimeraSlayer was shown to be more sensitive than earlier methods (Haas et al., 2011).
Furthermore, profiling a range of potential biomarkers may provide more sensitive or earlier indicators of pathological change.
