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Combining parasite density distribution data with infectivity data allows us to estimate how much of the infectious reservoir will be detectable with more sensitive diagnostics.
This could indicate that the reduced sensitivity of microscopy/RDT observed in low transmission settings (Fig. 1d) may be less severe with more sensitive diagnostics.
The wealth of quantitative PCR data collated for this study allowed us, for the first time, to investigate how the proportion of infections detected in different transmission settings might be expected to change with more sensitive diagnostics.
The unexpected magnitude of this overlap presents the unique opportunity to dissect the pathogenic mechanisms underlying multiple disease states in the expectation that this may lead to both more sensitive diagnostics and novel therapies.
Mass drug administration, more sensitive diagnostics, and gametocidal drugs may potentially improve interventions targeting the human reservoir of malaria parasites.
If the strategy must rely on diagnostic testing, more sensitive diagnostics capable of timely point-of-care results are needed to identify low density infections.
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With a more sensitive diagnostic, the expected drop-off in performance is smaller.
Published reports suggest that the CRP is a more sensitive diagnostic indicator of GCA and can be elevated when the ESR is normal.
In this review we have summarize the recent advances in proteogenomic approaches to develop more sensitive diagnostic and prognostic biomarkers which could be translated into improved clinical care and management of the disease.
The agar gel immunodiffusion (AGID) test and enzyme-linked immunosorbent assay (ELISA) based on detecting p26 antibodies are widely used, but there is an increasing need for developing a more sensitive diagnostic test utilizing other EIAV proteins.
Based on evidence from related apicomplexan species, we hypothesized that C. felis mitochondrial genes would exist at higher copy numbers than 18S and would be a more sensitive diagnostic target.
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