However, using a more sensitive cut-off of 9 [ 34, 46] 80 women (25%), were identified as likely to be depressed.
However, even after applying this more sensitive cut-off, the higher skin test prevalence found in Holstein cattle was not significantly altered compared to either Arsi or cross-breeds (Fig. 2; skin test prevalence Holstein, Arsi, crosses = 24.9, 13.9, 14.6%, odds ratios of Holsteins and crosses compared to Arsis: 2.052, 1.058).
Explorative analyses using alternative cut-off points for all the three diagnostic tests did not importantly change our findings on the relative strengths of the resulting NRIs, as can be expected since more sensitive cut-offs by definition lead to reduced specificities and vice versa.
For dichotomizing the FIT results, a cut-off level of 50 ng/ml was used, which is considered the most sensitive cut-off level for the OC-sensor.
This is surprising given the sensitive cut-off (of over 9) that was used on the EPDS.
We also evaluated the consequences of using more rigorous cut off points (correlation coefficient between two determinants >0.4) or less rigorous cut off points (coefficient >0.8).
ROC analysis was performed for each of the clinicopathologic parameters to set up more sensitive and specific immunohistochemistry cut-off scores for IGFBP-3 positivity.
We conducted another set of subsidiary analyses to assess the approach using a more sensitive but less specific cut-off to identify patients with metabolic syndrome (EHR metabolic syndrome diagnosed with two or more criteria present; see Additional file 1: Table S3).
Regarding the optimal cut-off of anti-CCP level, a recent study on pre-RA sera [ 18] suggested that lowering thresholds below that of the manufacturer's recommended cut-off level gave more sensitive prediction of future RA development.
Machado depicts himself as a tortured and sensitive bomb-thrower, cut off from any notion of home.
sTfR was overall more sensitive, even though it was evident that the ferritin sensitivity was influenced by selected cut-offs.
