Other investigations reported that intestinal cells react indeed more sensitive to agents from the basolateral side as compared to apical exposure [48].
Similarly, in this work we present evidence indicating that in the absence of laforin, cells become more sensitive to agents triggering ER-stress and that this situation correlates with an impairment of proteasomal function.
PERK−/− cells and cells expressing eIF2α(S51A) [16], [16] are more sensitive to agents that perturb protein folding in the ER, implying that reduced level of eIF2-GTP-tRNAMeti has an important role in activation of ER chaperones towards adaptation to ER stress.
When compared to hypoxia-sensitive M010b cells, hypoxia-tolerant M006x cells were more sensitive to agents that specifically interfere with aerobic respiration.
28 31 Finally, one study has suggested that the density distribution of blood platelet subpopulations may be affected, with an observed increase in less dense platelets that were more sensitive towards agents that induce aggregation.
Cell cycle phases in unlabeled (stalled) fractions were determined as described by Watson et al. DOI: http://dx.doi.org/10.7554/eLife.02725.036 As MMR-deficient tumors are compromised in their DSBR by HR activity, we wondered whether these tumors, similar to BRCA1-deficient tumors (Farmer et al., 2005), are more sensitive to agents that induce DSBs.
According to a study in C. pseudotuberculosis 1002 [ 52], compared with the wild type strain, the mutant 1002 strain is more sensitive to agents that generate nitrosative, acid (pH 5.5) and surface stresses, which indicates the important role SigE plays in the persistence of the bacterium in hostile environments.
Interestingly, doxorubicin and docetaxel significantly sensitized both ALDH− and ALDH + cells; however, ALDH− cells were more sensitive to these agents than the ALDH + cells and commercial BCSCs.
Leukemia cells were chosen in this study for initial screenings, because leukemia cells are frequently more sensitive to cytotoxic agents than most other tumor types.
These results indicated that Staphylococcus aureus ATCC 25923 was more sensitive to antimicrobial agents produced by examined isolates, compared to the other two indicators.
