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Compared with the commonly used MY09/11 primer set, our primer sets were broader in range and more sensitive against most papillomavirus types tested.
Accordingly, it can be speculated that leiomyomas may be more sensitive against MDM2 inhibition than matching myometrium.
As expected, HMC-1.1 cells were found to be more sensitive against several Kit TKI including imatinib, nilotinib, and masitinib than HMC-1.2 cells (Table 4).
In addition, we found that HMC-1.1 cells are more sensitive against sorafenib, tozasertib, and sunitinib compared to HMC-1.2 cells (Table 5).
Because as a rule fibroids express much higher levels of p14Arf, a major negative regulator of MDM2, than matching myometrium it was then analyzed if fibroids are more sensitive against nutlin-3 treatment than matching myometrium.
In fact, it has been described that HMC-1.2 cells exhibiting Kit D816V are more sensitive against the growth-inhibitory effect of rapamycin compared to HMC-1.1 cells (34).
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This data enhances greatly the ability to functionally characterize many proteins and demonstrates that our knowledge of protein functions can be increased based on more sensitive searches against the current databases.
"We are also working with some radio stations at district level to help journalists to be more sensitive about violence against women … so they can be aware … and be sensitive when reporting stories about women who experienced violence," says Luintel.
However, for the more sensitive iterative searches against consensus sequences, we also counted pairs from the same SCOP-fold as positives.
It will simply add another, more sensitive layer of defense against terrorist threats, said Anthony R. Coscia, chairman of the Port Authority of New York and New Jersey, which operates the airport.
The evaporating value of the euro hurts all Japanese companies that sell their goods and services in Europe, but Sony is more sensitive to yen swings against the currency than its local peers.
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