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Future studies will be needed to further define the important regulatory elements within the Erg gene that direct selected isoforms not only to the endothelium but also, perhaps more selectively, to the endocardium.
Pentamidine, a common drug used in the treatment of Leishmania infections, has been modified with boronic acids so that it might bind more selectively to the phosphodisaccharide repeating unit of the LPG.
We have found a novel multimetal oxide catalyst of the formula Aga−bMbV2Ox which allow significantly higher phthalic anhydride yield, since the new silver vanadium oxide catalysts can oxidize o-xylene significantly more selectively to form phthalic anhydride or intermediates than by using catalysts of the vanadium oxide/anatase type.
Highly specific structural entities are required for a ligand to interact with its specific receptor, which can be expected to respond much more selectively to significant molecular modifications.
DHA is a general ligand of PPARs, but binds more selectively to RXR transcription factors [ 29].
Alternatively within the current financing system, the intervention could be prescribed more selectively to patients at highest risk of not returning to work [ 18– 20].
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The answer is not simply to do less testing clinicians should continue to have a low threshold for considering pulmonary embolism but to test (and subsequently treat) more selectively and to consider alternative tests such as VQ scanning and ultrasonography when appropriate.
More applications also means schools can choose more selectively who to accept, and tailor the class to their exact requirements.
Adding to this obvious advantage to the patients, a boost dose for BCT is becoming more selectively applied to only those patients with a high risk of local recurrence, reducing the treatment by 1 1.5 weeks and decreasing the risk of fibrosis.
New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
Before our KO studies, the only known difference between RBX1 and RBX2 is that RBX1 is constitutively expressed and prefers to bind with Cul-2/VHL, whereas SAG is stress-inducible and more selectively binds to Cul-5/SOCS.
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