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Liposomal anthracyclines have the potential for more selective uptake by cancer cells and reduced cardiac toxicity.
Compared with non-FA-targeted prodrug 5, prodrug 4 showed higher and more selective uptake to tumors, presumably due to FR-mediated uptake.
Very concordant results can be derived from two comparative studies of SRPET/CT and FDG PET/CT [ 63, 64], in a total of 24 typical and 9 atypical BC: typical BC showed higher and more selective uptake on SRPET/CT than on FDG PET/CT, while the reverse was observed for atypical BC and higher grades of lung NET.
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As shown, prodrug 4 demonstrated higher (27 023 A.U). and more selective tumor uptake (tumor/skin ratio = 3 1) at 7 h than did the other prodrugs.
The application of liposome-encapsulated formulations of doxorubicin has been suggested as a strategy to minimize cardiac side effects and favour a more selective drug uptake by lymphoma cells (Allen & Martin, 2004).
The fasted animals displayed a more targeted and selective uptake of the glucose analogue tracer throughout the body, avoiding the general uptake throughout the whole digestive system due to food ingestion.
The results demonstrate that fluorescent ABPs show more rapid and selective uptake into tumors as well as overall brighter signals compared to substrate probes.
SR-BII over-expression was more efficient in enhancing HDL uptake, whereas over-expression of SR-BI was more efficient in increasing selective uptake [56].
-Trans-ε-viniferin (ε-viniferin, 5–200 μM), a dimer of resveratrol, concentration-dependently inhibited the uptake of [3H]noradrenaline and [3H]5-HT by synaptosomes from rat brain (being slightly but significantly more selective against [3H]noradrenaline) and the uptake of [3H]5-HT by human platelets.
Furthermore they demonstrated selective uptake in more recent attacks, which is specific to macrophage recruitment [ 95].
Erbes: We've certainly seen this outsourcing trend in the past, but what we're seeing now is uptake of more selective sourcing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com