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We introduce a more selective strategy, involving dye laser excitation and background subtraction by means of off-resonant excitation in combination with a bootstrap evaluation of sets of individual events.
There have been several attempts to generate animal models of cholinergic dysfunction by elimination of cholinergic neurons using electrolytic or excitotoxic methods, which are nonselective and destroy indistinctly both noncholinergic and cholinergic neurons, as well by the more selective strategy of cholinergic immunolesion, which preferentially destroy cholinergic neurons [1].
The more selective strategy of testing if the index ALT was over twice the upper limit of normal (C) has a higher predictive value, but is less sensitive.
A more selective strategy of viral testing all patients for viral hepatitis if they were born in countries where viral hepatitis was prevalent provided high efficiency with little loss of sensitivity.
Our single-center cohort of 40 Impella 5.0 implantations is original through its management of circulatory support going to a more selective strategy with an efficacy end point, which includes cardiac recovery or bridge to other therapy.
A more selective strategy considered by some laboratories to reduce costs might be to perform smear microscopy plus the liquid culture testing scenario on all sputum samples to ensure highest diagnostic sensitivity, but employ molecular testing only selectively for smear microscopy-positive samples (for MTB confirmation and rapid drug-resistance results).
Similar(54)
However, some cancers are resistant to proteasome inhibitors and more selective strategies are needed to circumvent this limitation.
Our expanding knowledge of the genetic repertoire of pancreas cancers promises to guide development of new, more selective strategies (Iacobuzio-Donahue, 2012).
Because of the ubiquitous role of TGF-β in regulating tissue fibrosis, more selective strategies have attempted to target specific components of the TGF-β signalling pathway.
More selective strategies to interfere with TGF-β signalling, perhaps even at a cell-specific level, will likely be required to modulate this signalling pathway for therapeutic gain in the context of HCC.
This provides a starting point to launch further prospective studies to confirm if this approach can lead to a more selective resuscitation strategy.
Related(20)
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