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These results suggest that the promoter regions of transporters expressed primarily in the kidney are under more selective pressure than those of transporters expressed primarily in the liver.
In contrast, kidney transporters are generally not as inducible as liver transporters, and there may be more selective pressure against genetic variation in their promoter regions that result in variation in the expression levels of the transporters.
Altogether, slow growth may be under more selective pressure in host-dependent bacteria than in free-living bacteria.
An additional, non-mutually exclusive possibility is that the advertisement call may have been under more selective pressure due to interference from environmental background noise [ 51].
It also seems likely that there would be more selective pressure to increase prey immobilization efficiency than acute toxicity or assimilation efficiency.
For instance, more selective pressure was on early zygotic genes than maternal genes [ 27]; therefore the measure of conservation increased during the maternal transcripts degrading process.
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Evolutionary engineering strategies are in fact complementary to metabolic engineering in the search for desired phenotypes through the imposition of one or more selective pressures.
Laterally transferred SMR genes from either SUG or SMP subclasses should have more selective pressures acting to maintain their isogenically conferred resistance and this trend is reflected in our analyses of both subclass sequences (Table 3 and Additional file 2).
In more detail, selection likely acts differently, the coding regions being more likely under purifying selection, whereas the IGS may experience more relaxed selective pressure [ 4].
As miRNA silencing relies on sequence complementarity to heterologous targets, this class tends to suffer more selective evolutionary pressure.
Current models of canalization suggest that genetic buffering occurs as a by-product of environmental canalization, which should evolve under stronger and more consistent selective pressure [18], [29].
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