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The development of more selective delivery systems for cancer diagnosis and chemotherapy is one of the most important goals of current anticancer research.
These include the more selective delivery and/or activation of cisplatin-related prodrugs and the discovery of new non-covalent interactions with the classical target, DNA.
At the same time, more selective delivery strategies are being developed, utilizing active cellular targeting upon reaching the tumor vicinity.
80 Thus, different strategies can be developed taking into consideration the special conditions which characterize affected skin and exploiting them to achieve a more selective delivery of the drug.
Furthermore, a better and more selective delivery of the drug to the dendritic and T-cell infiltrates in inflamed skin would reduce the side effects and increase the therapeutic activity of the drug.
Not only do our studies illuminate the structural basis of nucleoside selectivity by CNTs but they also provide proof of principle for utilizing membrane transporter structures for the design of drugs with more selective delivery (Han and Amidon, 2000; Majumdar et al., 2004).
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Since the conjugates are directed against CEA, which is overexpressed on colorectal cancers in comparison to that on normal tissues, these values suggest the potential for more selective photosensitiser delivery to this tumour type.
84 The therapy of skin infections can also profit from a more selective and effective delivery of the antimicrobial drug.
In addition, future studies could use a more selective approach to intervention delivery, as in practice only those individuals referred for therapy would receive such services.
It was described by other researchers that rod-shaped nanocarriers have unique characteristic and are more selective and effective in cancer delivery systems than when compared with the spherical shape of the same material [ 12].
Taken together, these studies demonstrate the utility of this conjugation strategy for developing improved systems for controlled intracellular delivery of PNA therapeutics, as well as more selective and sensitive nucleic acid biosensors.
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