Sentence examples for more selective agents from inspiring English sources
Our findings provide a molecular basis for AR subtype selectivity with implications for understanding the mechanisms governing allosteric modulation of these receptors, allowing the design of more selective agents for the treatment of ischemia-reperfusion injury, renal pathologies, and neuropathic pain.
Despite these side effects, GSIs is still an interesting class of drugs when compared to more selective agents as therapeutic antibodies.
This limitation might be bypassed to some extent as more selective agents are developed.
In order to delineate further the exact mechanisms involved in alcoholism more selective agents must be used.
The more selective agents can be produced in the gas phase and carefully bubbled through the appropriate procurer solution.
The beneficial effects achieved with these drugs have led to the introduction of more selective agents following detailed investigations into the pathogenesis of psoriasis.
They would enable the design of new, more selective, pharmacological agents.
Especially the 12, 13, 14, 15 and 18 seem to be the most promising lead structures for designing more selective cytotoxic agents as they have a lower toxicity for normal epithelial cells after 24-h incubation period.
However, the antiparasitic activity in Y strain trypomastigotes and host cell cytotoxicity in J774 macrophages revealed that compounds (10 and 18 21) are stronger and more selective antiparasitic agents than thiosemicarbazone (4).
Hence, the development of novel, and less toxic and anti-cancer agents remains an important and challenging goal of medicinal chemist worldwide, and much attention has recently been paid to the discovery and development of new, more selective anticancer agents [3, 6 8].
Among these strongly antiproliferative active molecules, the disclosed three thiophene bioisosteres (11, 17 and 18) are proposed as the most promising anticancer lead structures for the rational design of more selective antitumour agents because they proved to be markedly lower cytotoxic towards normal than tumour cells.
