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Moreover, the evolution of robustness is likely dependent upon the environmental stability of the cell, with more fluctuating environments leading to the emergence and fixation of more robust molecules.
Of relevance is the fact that the variability in sequence compositions that share a common structure was considerable and allowed unraveling a precise pattern by which the more robust molecules to environmental perturbations were also those more robust to mutational perturbations.
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As such measurements become more robust, single-molecule metrology tools are being dramatically enhanced by combining additional signals providing further chemical, physical, and electronic information.
Fast and rigorous model selection and model averaging (Posada 2008) may provide more robust classifications of RNA molecules and new insights into their function.
Strongly doped silicon has been proved to be an excellent contact to interconnect to molecules, even more robust than gold [22].
Therefore, hydrophobicity (causing a poor solubility into biological buffers) (collisional), quenching in aqueous media and irreversible photodegradation under intense excitation light [11, 22], requires encapsulation so that to produce monodisperse and more robust emitters from organic dye molecules and amorphous silica.
We are currently embarking on deep sequencing of hES and hiPS cells to gain a more robust list of the cell surface molecules that can be probed for involvement in human pluripotent cell morphology.
A later time point post injection, such as three days, may yield a more robust effect on expression of these molecules (Buttini et al., 1996).
Small molecule quantification has several more robust options for quantification compared to proteins, with the benefit that the molecule analyzed is typically intact, and not a digestion product.
The difficulties with prebiotic ribose synthesis and nucleoside formation have led some to speculate that perhaps a simpler genetic molecule with a more robust prebiotic synthesis preceded RNA (Joyce et al. 1987).
Nevertheless, the apparent difficulty of RNA's prebiotic synthesis has led relatively few of those interested in the origin of life to explore the prebiotic synthesis of other molecules that are perhaps more robust (e.g., Nelson et al., 2000).
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