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In general, noncovalent and covalent attachment chemistries have been used to immobilize proteins to solid surfaces with the latter reported to provide more robust linkages, hence, less susceptibility to detachment or denaturation.
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The MK statistic, which compares the number of polymorphic sites rather than using only frequency information, is generally considered to be more robust to linkage effects than frequency-based statistics [ 20, 27].
It uses the mean similarity across all cluster data points and is thus more robust than single-linkage methods.
However, even if this is the case, the conservative design of the method allows it to provide more robust statistical evidence of linkage than that provided by the original GWLS.
Several studies have demonstrated that probabilistic linkage techniques are more robust against errors, and result in better linkage quality than deterministic methods [ 5- 7].
This shifting selection during the course of X chromosome evolution might result in strengthened compensation or selection for gene content that favors X-linkage for genes with more robust gene regulation.
Our second objective was to develop an expansive set of SNPs that can be used for more robust inferences of population structure, construction of linkage maps, and genomic scans of selection.
It is evident that the sulfur gold linkages in DTC-SAMs are substantially more robust than those in thiol SAMs.
Average-linkage clustering is known to be more robust against outliers [31].
GST-ATXN3(Q22)2UIM showed the same cleavage activity as GST-ATXN3(Q22)3UIM: Limited cleavage of K48-linked Ub chains, more robust cleavage of K63-linked Ub residues and mixed linkage chains, and vigorous cleavage of the higher molecular weight Ub chains that likely represent dimers of Ub4 or Ub6 [16].
Hence the analysis based on the conditional genotypic distribution is more robust to non-randomness of the samples to infer linkage disequilibrium in populations of interest than that based on the joint genotypic distribution.
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