While gene expression profiles tend to be more robust with inclusion of a larger set of genes [ 9], we decided to limit the developed profile to a relatively small number of genes with optimal performance.
This finding suggests a more general approach for assessing model performance where the point estimates and confidence intervals are more robust to inclusion of additional information, probably because of less bias in the initial estimates from nonindependence in the observations, particularly from excluded exposure information.
The correlation between the increase in TERalb during rosiglitazone treatment and baseline Ewing score was even more robust after inclusion of all the TERalb results (r = 0.72, p = 0.002), showing that the exclusion of qualitative weak TERalb measurements neither biased nor caused the relationship.
The inclusion of more robust and variable floral and faunal data would serve to increase the sensitivity of the model to these parameters.
More robust data will come from future inclusion of additional cases and further standardized assay conditions, including development of assays for absolute quantification of Stat5a and Stat5b proteins in cellular compartments within the tumors, as has been achieved for other proteins [ 56].
From this perspective, it would be possible to create acquired knowledge inclusion models that are more robust.
HCA is considered more robust in the generation of classes than PCA due to inclusion of additional dimensions [25], [31] and correctly grouped 86 of 90 samples, with only 4 spectra from II-3 improperly clustered with FH (Figure 3B).
Inclusion of more Asian countries would provide more robust estimates.
A higher level of filtering and inclusion of the laboratory fee items show more robust patterns.
The proposed method, consisting of both filtration of diagnostic codes and inclusion of fee item data, is inherently more robust than simple reliance on diagnostic code.
