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"We believed we needed a more robust cell type if you go for cell-based therapies," he said.
With the recent growth of interest in cell-based therapies and radiolabeled cell products, there is a need to develop more robust cell labeling and imaging methods for in vivo tracking of living cells.
In addition, the results obtained by the robust MIP model indicated the advantages of robust optimization in generating more robust cell configurations with less cost over the considering expected value of uncertain parameters in a deterministic mean-value based model.
Thus, one explanation for the slow resolution of foci in hESCs may be more robust cell cycle checkpoints (other than G1/S) and slower DDR recovery [34].
Although this effect was easily observed in monocytes incubated with the 10 kDa dCGN (Fig. 5B), a more robust cell aggregation was observed in monocytes incubated with the 40 kDa dCGN (Fig. 5C).
A BCG vaccine that is able to induce a more robust cell mediated response characterized by higher induction of IFN-γ and IL-12 could potentially alleviate the "blocking" hypothesis presented in [44], especially in regions that administer BCG after potential exposure to mycobacteria through the water or soil can occur (e.g. after a newborn has left the hospital).
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In other studies, this approach has shown that the more robust cells will outcompete the leftover damaged cells and will survive.
Here, we propose a two-step hybrid strategy to produce a more robust cell-based cancer vaccine in situ.
The metaplastic shift in the notochord and arch centra may be induced to produce more robust cells, able to withstand increased mechanical load.
An alternative explanation for the ptc phenotype is that ptc mutant CySCs induce death in neighboring wild-type cells, akin to classical cell competition in which more robust cells kill and take the place of weaker cells (Amoyel & Bach, 2014).
How then does a senescing cell population generate a more robust cancer cell?
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Justyna Jupowicz-Kozak
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