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Furthermore, ASCs demonstrated a dose response relationship, with the highest dose chosen inducing more robust bone regeneration.
However, a more sophisticated approach may utilize hASCs engrafted onto a defect laden or impregnated with growth factors to promote even more robust bone formation.
The differences in CSA could also be caused by differences in selection mechanisms favoring more robust bone structure during medieval times.
With more robust bone, they recommended trying to achieve a press-fit fixation and adding screws.
This would have resulted in a more robust bone marrow response than in nonanemic, recently infected patients (47).
By contrast, IGFBP3KO mice, which also show decreases in serum IGF1, exhibited a more robust bone phenotype when compared with controls (Yakar et al., 2009b).
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Consequently, more robust new bone formation is seen in the critical-sized bone defect model with ex vivo gene therapy than seen with the use of rhBMP-2 [ 41].
Interestingly, animals from the WT +/+ background have a slightly more robust cortical bone phenotype than those of the WT HBM−, whereas WT HBM− have a more robust trabecular bone phenotype than those of the WT +/+.
The lower rate of complications in patients with A/H may result from the shortening of treatment time associated with more robust new bone formation at the distraction gap.
We found that free IGF1 in KIR mice promoted increases in all morphological bone traits, resulting in more robust, stronger bones when compared with controls.
The stresses in the plates were much higher than those in the bone but the material properties of plates are also more robust compared with bone.
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