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Furthermore, it is known that enhancers exhibit negligible activity when transiently transfected but far more robust activity upon genomic integration.
Fourth, the CR4 element of the mouse Oct4 DE exhibits a more robust activity in rbiPSCs than in rbESCs.
More robust activity was seen with ixabepilone, although this was not significantly different from that observed with docetaxel (Galsky et al, 2005; Hussain et al, 2005).
Data from literature suggest that a more robust activity of novel dual PI3K/mTOR inhibitors, compared with either PI3K or mTOR inhibitors, is required for efficient suppression of tumour growth when multiple alterations of the PI3K pathway exist (Sabbah et al, 2011).
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The authors speculate that perhaps the dissociation of genomic DNA caused by the RNA-DNA interactions mediated by the guide RNA affected nearby transcription complexes; they suggest that new dCas9-based activator platforms may show more robust transcriptional activity [ 105].
It indicated that MPA-QDs induced a more robust proinflammatory activity than AMP-QDs in the liver and spleen.
Our data thus far have demonstrated that RecANg catalyzes more strand exchange at early time points and exhibits a more robust ATPase activity than RecAEc on DNA substrates commonly used in the laboratory, both in the context of stand exchange and alone.
EWS/Fli-1 exogenous expression results in more robust luciferase activity compared with Fli-1 alone.
It will be important therefore to assess whether utilizing the ΔN-PINK1 product, or the PINK1-F104A mutant, one will be able to observe a more robust kinase activity of PINK1, thus facilitating the identification of bona fide PINK1 kinase substrates and potential new therapeutic targets for PD.
Our results, whilst they suggest that outcome-based incentives may be more robust than activity-based, also highlight the importance of context in determining the success of agri-environmental incentive schemes.
Figure 5 illustrated a sandwich electrochemical cytosensor enhanced by robust nonenzymatic hybrid nanoelectrocatalysts.A kind of Fe3O4@ Ag Pd bimetallic nanocage core satellite hybrid NP was found possessing significantly more robust electrocatalytic activities than the enzymatic peroxidase/H2O2 system for signal amplification in electrochemical cytosensing.
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