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Findings can inform more rigorously designed studies of the intervention.
The pilot trials "cry out for" larger and more rigorously designed studies known as randomized, double-blind, placebo-controlled trials to provide definitive answers, Dr. King said.
The newer trials, more rigorously designed than the Dutch one, are expected to provide clearer answers about whether the drugs can ward off Alzheimer's.
Thus, more rigorously designed RCTs are necessary to examine the effect of probiotics on body weight in greater detail.
More rigorously designed trials should be implemented to establish comparative efficacy and safety of drugs used to treat chronic and acute LBP.
Our results provide a foundation for future research in this area, which we recommend as including more rigorously designed, large, randomized studies.
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Some earlier studies in ICU patients suggested that early tracheotomy was associated with better outcomes than late tracheotomy [ 13– 16], but more recent, rigorously designed randomized controlled trials (RCTs) did not show a significant survival benefit [ 17– 17].
However, evidence from more recent rigorously designed, conducted and analyzed studies now suggest consistent relationships between migraine and vasospastic disorders such as variant angina and Raynaud's phenomenon, as well as ischemic stroke in young women [ 20, 21].
Despite recent progress in these areas, more data from rigorously designed studies are needed to better inform the clinical management of patients with asymptomatic PHPT.
Thus, more evidence from rigorously designed randomised controlled trials with objective measures of physical activity is needed.
Results from larger rigorously designed studies will help draw more definitive conclusions.
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