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The more rigorous trials included 12 hours apprenticing as a groundskeeper at Shea Stadium and 14 hours training as a sous-chef at Le Bernardin restaurant in Manhattan.
This case raises the question of whether the F.D.A. should demand more rigorous trials before a device is granted a humanitarian exemption.
In the long run, this hurts both patients and other companies that are committed to performing more rigorous trials.
More rigorous trials with larger numbers of participants and a control group are needed to strengthen the conclusions.
More rigorous trials are required to confirm these preliminary estimates of effectiveness.
Results from trials of other types of study design presented here warrant further study in more rigorous trials.
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Mr. Abdullah blamed the Americans for failing to push Iraqis to hold a more rigorous trial.
But the bigger and more rigorous trial will come next Saturday when more than 4,000 high school boys and girls competitors from six states take part in the 12-hour Bishop Loughlin Games.
Many of the recent trials have addressed deficiencies of the previous ones with more rigorous trial design, including more specific patient selection criteria (ensure homogeneity of stroke location and severity), stratified randomization algorithms (time-to-treat), narrowed therapeutic time-window and pharmacokinetic monitoring.
Thus a larger more rigorous trial is required to confirm the pilot data.
An urgent need exists for a larger, more rigorous trial that includes infants unselected for feeding method to clarify whether L reuteri is effective for infant colic in the general population.
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more rigorous definitions
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more human trials
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com