In the cases of the HCS- and CMS-containing clusters, differential conservation of active site residues predicted to be in contact with the α-ketoacid substrates suggests these activities are examples of pseudoconvergent evolution, but more rigorous phylogenetic and functional analyses are required to further support this hypothesis.
More rigorous testing including various functional classes of genes combined with the analysis of cis-regulatory divergence needs to be performed to estimate the relative impact of cis- and trans-effects on gene regulation in allopolyploids.
As more ESTs are added to the sequence database, the sample sizes of these functional classes will become larger and a more rigorous test of the role of functional class in phylogenetic analysis may be possible.
Future evaluations would benefit from incorporating emerging concepts in ecology such as functional traits to assess recovery of functionality, more rigorous experimental designs, enhanced comparisons among projects, longer term monitoring and reporting failure.
The Ontario WSIB should continue to incorporate established prognostic factors for recovery into their baseline data collection forms, as well as outcomes of direct importance to patients, such as functional recovery, to facilitate more rigorous analyses of their administrative data.
During postnatal brain development, the brain's wiring pattern is further sculpted and modulated to become the full facsimile of the adult human brain, with functional brain network refinement being more rigorous than structural brain network maturation.
More rigorous studies with larger sample sizes, detailed HPV data and SNP functional relevance are warranted to replicate our findings and identify the underlying mechanism(s) of these SNPs in the etiology of SCCHN.
System diagrams, as widely used in environmental sciences and engineering [ 66], provide a more rigorous means of conceptualising complex problems on the basis of their inherent functional or ecological structure.
The minimalists were more rigorous.
So was adjusting to more rigorous competition.
