Sentence examples for more rigorous dose from inspiring English sources

We chose this more rigorous dose regimen of TMZ according to the publications of Wick et al 16 who reported a progression-free survival (PFS) as high as 48% with an overall survival for 12 months of 81% Toxicity was evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE; V.3.0).

As we move to implement changes, regulatory agencies and industry are beginning to adopt tiered approaches, which leverage high-throughput screening technologies for prioritization and read across, followed by interrogation of "hit chemicals" with more rigorous dose-response assessment either in fit-for-purpose human cell-based assays or with traditional in vivo tests.

Thus, the effects may be context-dependent or require a more rigorous analysis of dosing schedule or pharmacokinetics.

The KEDRF provides a foundation for more rigorous and quantitative descriptions of dose-response at dose levels relevant to public health.

This study may have comprised cases also included in our analysis, but we believe our study was more rigorous as it examined both the dose and duration of NSAID exposure rather than the number of NSAID prescriptions issued; similarly, the UTS follow-up time (a minimum of 5 years) and the median follow-up time (10.6 years) in our study were longer than in the earlier study (at least 3 years).

A more rigorous dose response evaluation to ascertain the optimal dose and schedule required to delay or prevent cellular transformation may enable the use of lower doses that might not cause cardiovascular toxicity.

In addition, lower toxicity in our study may have been more limited because of the early and rigorous dose reductions according to our protocol.

The phenomenon that is described within the current paper concerns resistant phenotypes; thus, applying more rigorous photodynamic conditions (like a higher light dose or sensitizer concentration) this resistance could be overcome.

In October 2007, the study reopened with reduction in chemotherapy doses in addition to more rigorous supportive care requirements.

A recommendation regarding the opioid of choice for routine use in patients undergoing CABG surgery awaits more rigorous studies of recovery and cost after equipotent doses of fentanyl and sufentanil.

Accessing dose information from these sources is more rigorous and less prone to selection biases or judgements around 'standard' scanning practices the current DRL survey methodologies risk [ 31].