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Moreover, the mtSNPs allow for a more rigorous classification of mtDNAs into hgs due to the (average) low mutation rate characterizing these SNPs compared with the mutation rate in the control region [33].
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Following closer inspection, we found that a majority (∼60%) of the differences in these ratios were due to the higher numbers of unclassified genera within the Lachnospiraceae family in samples A and B, pointing towards the need for a more rigorous taxonomic classification within phyla largely dominated by yet uncultured phylotypes, such as is the case for the Lachnospiraceae [8].
The simple ≥ 9 cutoff rule is desirable from the standpoints of interpretability and logistical ease, but more rigorous statistical classification tools might achieve better sensitivity and specificity.
But this has not deterred St. Émilion's leaders from making the classification ever more rigorous.
Her view is that "the whole science of classification has become much more rigorous now" and has been stimulated.
The idea of this classification system is that a more rigorous study design would present evidence that is more reliable in terms of its clinical applications and in its ability to change health policy.
This information could then be used to create a classification of data sources, from more rigorous to doubtful, in order to assess the quality of the data.
Top Secret/SAP, or special access program, is a classified designation "deemed so sensitive that it requires more rigorous protection than other classified information," said Steven Aftergood, a classification expert and the director of the Project on Government Secrecy at the Federation of American Scientists.
Attempts to conduct more rigorous phenotyping and a move towards a mechanism-based classification of pain syndromes might help resolve this confounding factor [ 55].
These ideas can be made more rigorous by noting that with greater homogeneity partition by partition, there are fewer classification errors overall.
The minimalists were more rigorous.
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CEO of Professional Science Editing for Scientists @ prosciediting.com