Sentence examples for more rigid substrates from inspiring English sources

As shown in Figure 4A, cells seeded on more rigid substrates expressed higher levels of phosphorylated MLC (pMLC), implying that ROCK activity increased on more rigid substrates.

In contrast, both PC-3 and mPanc96 cells failed to show significant differences in migration when plated on soft versus more rigid substrates (Fig. 7C).

The ability to spread on more rigid substrates also correlated with the ability of A549 and MDA-MB-231 cells to migrate.

This is at least in part due to an increase in TGF-ß1 expression by cells on more rigid substrates (Figure 5C).

Similar to previous studies, this work illustrated that growth of cells on more rigid substrates promoted fibronectin assembly and activation of focal adhesion kinase (FAK).

On more rigid substrates (E ∼ 900 kPa), αSMA expression can be induced through the addition of TGFβ1, but higher concentrations are needed on less rigid substrates.

These data support the conclusion that growth on a more rigid substrate promotes smooth muscle cell conversion to the contractile phenotype.

The formation of focal adhesions on micropost arrays and flat surfaces varied depending on both the substrate stiffness (where shorter posts correspond to a more rigid substrate) and ECM protein pattern.

A more rigid structure, however, improves substrate recognition, allowing for tighter substrate binding and lower Km values.

Cell adhesion controls cell cycle progression by mechanotransducing the rigidity of the substrate.19 We found that more MCF10A cells cycle on rigid substrates with 1.8 kPa stiffness than on softer substrates with 0.2 kPa stiffness (Fig. 5b).

Thus, direct fabricating AAO onto rigid substrates become a more convenient and important technique to prepare vertical nanostructures.