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KS chains can be modified by O-sulphation of the hydroxyl groups but in a much more restricted pattern when compared with CS.
Expression analysis of the three FAM20 family members in mammalian tissues and hematopoietic cells showed that FAM20A is expressed in a much more restricted pattern that the other two members.
One study reported that, in comparisons with controls, patients with persistent postoperative seizures showed evidence of widespread cortical involvement, whereas patients rendered seizure free showed more restricted pattern of cortical atrophy, although no direct comparisons were performed between patient outcome groups [Yasuda et al., 2010].
Gata4 transcripts containing E1b' exhibited a more restricted pattern with expression detected as a doublet band (long and short forms) only in heart, stomach, and gonads (Figure 2B).
To determine a more restricted pattern, we analyzed ZENK expression in the brains of deafened female zebra finches placed in the rotating wheel in the dark.
In contrast to MLK3, which is widely expressed in many tissues [21], the MLK family member dual leucine zipper-bearing kinase (DLK) exhibits a more restricted pattern of expression [22], [23].
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Consistent with these observations, we note that nodal-regulated genes tend to be expressed in more restricted patterns than do activin-regulated genes (Fig. 2A F).
The diverse pattern was generally found in patients with a high acute phase response, whereas patients without elevated acute phase proteins were more likely to demonstrate a restricted pattern.
It is likely that as more miRNAs are characterized, many will have a tissue or developmentally restricted pattern of expression.
Although most known Z lineage genes encode the typical peptide anchoring residues, these genes are considered non-classical due to low levels of polymorphism and more restricted tissue expression patterns [ 29, 34].
Whereas some caleosins exhibited more restricted, tissue-specific patterns of expression, such as Clo6 and Clo10, others such as Clo7, were detected in almost all rye and triticale tissues sampled.
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