NAT2 has a more restricted expression profile, being predominantly expressed in the liver, small intestine and colon, and prefers bulkier substrates such as sulphamethazine, isoniazid, procainamide, and dapsone (reviewed in [ 10]).
This is particularly interesting since some of the subunits are ubiquitously expressed whereas others display a more restricted expression profile.
The common clathrin heavy chain, CHC17 is ubiquitously expressed, whereas CHC22 displays a more restricted expression pattern.
A more restricted expression pattern is shown by Dll4, that is exclusively expressed by V2 differentiating neurons [14], [33], and by Jag2, which is expressed in differentiated MNs [32].
While Cybb (encoding gp91phox) has a more restricted expression in leukocytes, Ncf1 (encoding p47phox) is more widely expressed in both leukocytes and nonleukocytes.
For example, RACK1 is ubiquitously expressed in the adult mouse brain, however, a much more restricted expression pattern is observed for PKCβII [ 71, 228].
There are three alpha-isoforms: HIF-1α is nearly ubiquitously expressed whereas HIF-2α and HIF-3α show a more restricted expression pattern.
Mkrn1 is widely expressed in adult mouse tissues; however, during embryogenesis, Mkrn1 exhibits more restricted expression 19 28.
For example, H2-T23 was expressed widely, whereas the H2-T11 gene paralog showed a much more restricted expression pattern.
Most murine TMC genes are widely expressed at relatively low transcription levels; some TMC genes, however, display more restricted expression patterns.
VEGFR-2 has a more restricted expression on endothelial cells and is upregulated once these cells proliferate during angiogenesis in the tumor vasculature.
