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It is likely, however that the major advance that stem cells have over more restricted cell types is their ability to modulate the responses of the immune system and to influence endogenous tissue stem cells to accentuate repair.
This may represent the more restricted cell cycle expression of pHH3 than Ki67 (25, 25).
Nevertheless, our unpublished data indicate that, similar to the bivalent domains at promoters, simultaneous H3K4me1/H3K27me3 marking at enhancers is much less prevalent in more restricted cell types compared with both human and mouse ESCs (A Rada-Iglesias, R Bajpai and J Wysocka, unpublished observations).
The natural occurrence of both the composite interaction and the sequence of its component cellular interactions is best observed during the in situ development of whole brain, since many of the component cellular interactions may be unavailable or inoperative in more restricted cell and tissue models.
CMPs may form two more restricted cell types, the granulocyte-macrophage progenitors (GMPs) and the megakaryocyte-erythrocyte progenitors.
Similar(55)
Here we assume that LTP cells are stem-like cells, while STP cells are more restricted progenitor cells.
Additional studies in salivary and other glands have also revealed that multipotent embryonic progenitor cells seem to temporally transition to more restricted progenitor cell types to regulate normal gland homeostasis; however, the multi-lineage potential of such cells can be revealed during tissue regeneration or following transplantation.
Interestingly, in contrast to TBP genes that are ubiquitously expressed, TRF genes exhibit more restricted cell-type specificity, being preferentially expressed in embryos and/or reproductive organs [8],[9].
In contrast to the ligands, the receptors show much more restricted cell-type expression.
Hence, we conclude that pSSCs represent a heterogeneous population of undifferentiated stem cells and more restricted progenitor cells.
This locus is known to have a more restricted beta cell expression than the Ins2 locus, which displays transient expression in the hypothalamus and other brain structures [ 24].
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