Due to the fact that the premedication in the more-responsive subgroups was lower than that in the less-responsive subgroups, the relative increase in MPH dosage in these groups was the highest after the medication switch.
On a descriptive level, children in the more-responsive groups were treated less intensively prior to study start; statistical analysis confirmed that lower MPH dose before medication switch was linked to a higher probability of falling into a more-responsive subgroup.
Discrimination against entire subgroups could also occur if, for example, genetic variants were found to correlate with a more favorable vaccine or treatment response, but only in certain ethnic groups; also, drug development might focus on these 'more responsive' subgroups.
Bigger is not more responsive, nor more responsible -- just bigger!
The hierarchical clustering on the basis of their expression levels suggested that the NF-YA subgroup is more responsive to moderate drought.
Figure 1 shows the DTSQc was markedly more responsive than the DTSQsDiff across all subgroups, including the Not at Ceiling group.
Although a subgroup of patients was more responsive to the mesalazine treatment, our data did not allow to identify these subjects.
Therefore, the identification of miRNAs that control TNBC initiation and progression could identify individuals that have more aggressive disease and may also help to identify subgroups of patients that are more responsive to particular treatments within these subtypes.
When addressing individual-level responsiveness, too, SPADI was more responsive.
The relative importance of these pathways, which share the final common pathway of fibrogenesis, may further vary across individuals, highlighting the importance of identifying subgroups of phenotypes, which may be more responsive to particular therapies.
