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However, papilloedama is a delayed consequence of chronic CSF accumulation in the retrobulbar optic nerve dural sheath due to raised pressure in CSF in cranial cavity, and direct measurement of such CSF accumulation may provide an earlier and more responsive measure of intracranial hypertension.
Pain-free grip strength is a more responsive measure of outcome than maximum grip strength for patients with Lateral Epicondylalgia.
A more responsive measure should show larger differences between the self-reported groups.
The observed difference in effect size between the FADI (ES = 0.52) or the FADI Sport (ES = 0.71), representing a medium size of change [ 18], and the AJFAT score (ES = 2.52), representing a large size of change, may indicate that the AJFAT is a more responsive measure.
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A more responsive outcome measure may be disability-adjusted life years (DALYs), which can be used as an outcome measure to assess whether the population's burden of illness has improved with new education and training strategies.
The HAQ has been found to be more responsive for measuring functioning than the WOMAC questionnaire; a widely used in hip and knee OA [ 40].
A recent paper concluded that there was a major need for more responsive outcome measures for both symptom and structure modifying agents for human OA and a need to focus on developing and qualifying biomarkers to enable the development of DMOADs.
A straightforward solution would be to attempt to produce a better, more responsive, generic index measure.
The smaller the MID or larger the effect size, the more responsive an outcome measure is considered to be.
It is possible that perceived comfort may have been a more suitable and responsive measure for this study.
For both groups, At Ceiling (Floor)/Not at Ceiling (Floor), therefore, the change measure is significantly more responsive than the DTSQsDiff measure.
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