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Once the frequency of the dhfr/dhps quintuple mutation rises, selection for more resistant haplotypes takes place, as in the case of Korogwe, where the quintuple mutation reached saturation and there was a high frequency of a sixth mutation, the dhps 581G mutation [26].
Weinreich et al. [1] considered two selection models, with potential next steps in a pathway having either equal probabilities of occurrence ("truncating selection model") or with more resistant haplotypes having greater probabilities, with different probabilities given by Extreme Value Theory ("EVT model").
Similar(58)
This variant was only present on the same haplotype as the kdr allele and its presence alone was associated with a much more strongly resistant haplotype, when compared to the common kdr-containing haplotype (Figure 7a).
Haplotype StAOS2 A 691 C 692 was more resistant to late blight and later maturing.
Indeed several studies showed that inbred individuals are more prone to deleterious effect of infectious diseases than outbred individuals [42], [43] and some resistant haplotypes could be identified [44], [45].
Others are more resistant.
English firefighters are more resistant to change.
Conservative Republicans are more resistant.
But some museums are becoming more resistant.
New, more resistant species have been identified.
But Mr. Syron was more resistant.
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