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This may have selected more resistant clones in our study.
Chemotherapy may be able to kill sensitive cells and leave behind the more resistant clones.
However, should prevention initially fail and a tumour be diagnosed and resected, any residual or metastatic cells are likely to contain more resistant clones than the corresponding situation for a post-diagnostic tumour.
A greater understanding of how the bacteria have evolved in any geographical area can help us to rapidly identify new outbreak strains and even prevent emergence and diffusion of more resistant clones [ 17].
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Interestingly this dose effect was not observed for PCT90 or PCT50; one explanation is that the more resistant clone(s) in a polyclonal infection may require more parasite lifecycles before complete killing occurs, and that PCT50 and PCT90 values reflect killing of the more sensitive clones.
During the course of 4 weeks, more resistant cell clones most probably do not emerge.
Pulsing with taxol resulted in more highly resistant clones (up to 51.4-fold).
For example, intuitive assumptions might be that patients who experience later than normal recurrence harbor more indolent resistant clones with lower fitnesses or that a smaller tumor size at recurrence signifies a less diverse relapsed tumor population.
Thus, genomic heterogeneity may be an attractive therapeutic target to prevent evolution of more aggressive or resistant clones.
Discordant phenotypes in primary and recurrent breast cancers have usually been interpreted as a genuine switch in tumor biology or intratumoral heterogeneity, with treatment-related selection of more-aggressive and resistant clones [ 36, 37].
More ap-resistant clones were detected using WG5 as recipient than C600nalR.
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