Powerful methods of genetic engineering have now been extended to physiologically more relevant species, particularly the pig, opening the prospect of more representative, genetically defined, cancer models at human scale.
First, NGS allows for genome-wide screening of markers, which may lead to a more representative estimation of genetic variation within and between populations.
TE insertion polymorphism is common enough to provide an efficient tool for strain typing, population studies and phylogeny [ 94, 95], and far more representative of the genetic diversity than phenotypic polymorphism.
In contrast to standard phylogenetic markers, AFLP variation is spread across the whole genome, spanning both coding and non-coding DNA regions and may therefore be more representative of overall genetic patterns present as well as being highly informative for phylogenetic analyses at the low phylogenetic level [ 23, 24].
The design of this SNP chip was informed by low-coverage resequencing of 12 CEPH-HGDP samples and the low-coverage sequencing of the archaic hominids Neanderthal and Denisovan, and therefore the SNPs represented on the chip are likely to be more representative of common global genetic diversity.
One, if several lesions were detected by high resolution imaging in a patient, characterizing biopsies from all or a large fraction will be more representative and potentially reveal genetic heterogeneity among them.
We also recommend expanding the geographical area of sampling in order to provide a much more representative perspective of the species' genetic diversity.
Using field-collected spores directly for genotyping would provide a more representative sample of the actual genetic diversity in an AMF population than using in vitro fungal cultures, as factors such as host plants used during cultivation could bias the composition of successfully established isolates [ 14].
Therefore, integrating tumorigenic potential and genetic heterogeneity studies is germane for a more representative picture of the extent to which individual tumorigenic cells contribute to genetic diversification.
The equine genome draft was derived from DNA of a single Thoroughbred mare, while our EPLD-PCR data were generated from animals of various genetic backgrounds and may thus be more representative of this challenging genome region.
