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Robust modelling of curvilinear change requires larger samples or more repeated measures.
In this sample, 194 men (44.3%) had two or more repeated measures, resulting in 636 observations for analysis.
Several improvements, in addition to a larger sample and more repeated measures, would have increased confidence in the results of our study.
The WHI-CT had more repeated measures available, but we were only able to utilize three time points (baseline, year 1, year 3) due to high levels of missing data at later time points.
Twenty-one of these patients had 3 or more repeated measures (median 5; range: 3 10) and were followed-up for a median of 65 months (range: 16 107).
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In Experiment 1 we studied FB- and PA-based learning in PD patients and controls and, as an improvement on previous methods, used a more powerful repeated measures design and more equivalent test phases during FB and PA conditions (including altering the FB condition to remove time limits on responding).
Investigators should seek to incorporate more repeat measures of physical and cognitive functioning in order to identify which measures change first.
Given the complexity of estimating power for HLM models, these calculations are based upon a more simple repeated measures ANOVA model [ 59], with an attrition rate (i.e., not followed after baseline assessment) estimated to be 15%.
As spending on maternity services was available for each year included, we examined the year on year effect of changes in spending on infant and perinatal mortality rates by fitting a more complex repeated measures analysis including a within-PCT spending term by year.
Otherwise, it is more efficient to have more than two repeated measures.
In addition, GEE allows for a wide variety of correlation structures to be explicitly modeled and is more interpretable that repeated measures ANOVA.
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