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Recently, more repeat tracts of TTTAGGG have been assembled (ToxoDB v9.0).
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A total of 158 SSRs of five or more homogeneous repeat tracts were identified.
Longer unstable triplet repeat tracts are more prone to expansion as opposed to contraction, in addition to being predisposed to generational transmission.
First, repeat tracts containing three or more repeat units were restricted to MLEE lineage A as described above and belonged to a cluster (I) of perfect repeat units.
Based on previous investigations [ 33- 35], searches were made of the genome sequence data for homopolymeric tracts greater than or equal to (G 7, (C 7, (A 9, and (T 9 and for dinucleotide repeat tracts with five or more copies of the dinucleotide.
Finally, repeat tracts in which the 3′-CAA repeat has changed to a CAG are markedly more unstable (see Figure 1a).
Through their association with TNRs, protein homo-AA repeat tracts have been implicated in a range of human diseases [ 16] and are more likely to be involved in transcriptional regulation [ 15], possibly due to the structural characteristics of the homo-AA tract.
Mittelman, D. et al. Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instabreaks in human cells.
Lin, Y., Dion, V. & Wilson, J. H. Transcription promotes contraction of CAG repeat tracts in human cells.
SELL MORE, repeat.
Programmable nucleases were proposed to provide a tool to shorten repeat tracts and a much needed cure59.
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