Sentence examples for more repeat instabilities from inspiring English sources

We also showed for the first time that tumor genomes with an MSI phenotype, which indicates a defect mismatch repair system, contain more repeat instabilities than microsatellite stable tumors.

We found that MSI tumors have more genes with repeat instability than MSS tumors (2558 ± 274 and 2332 ± 364 genes, respectively, for promoter regions, WRS test, P = 0.15; 2371 ± 840 and 1109 ± 327, respectively, for exons, P = 0.003, see Fig.  3).

Tri- and tetranucleotide microsatellite instability (MI) is characterised by the insertion or deletion of one or more repeat units of three or four nucleotides.

SELL MORE, repeat.

If repeat instability is essential, more attention needs to be paid to the nature, density and localization of the repeat interruptions.

Future studies using more data and more advanced technologies will enhance this understanding further, in order to develop more effective molecular diagnostic approaches centered on repeat instability.

We find that tumors with a microsatellite instable (MSI) phenotype are enriched in genes with repeat instability, and that tumor genomes have significantly more genes with repeat instability compared to healthy tissues.

Tandem arrays of simple repeats such as mono-, tri-, and tetranucleotides are common in eukaryotic genomes, and repeat instability is the cause for more than 40 neurological, neurodegenerative and neuromuscular diseases [1].

Increased expression of the MMR factors is known to be involved in repeat instability (López Castel et al., 2010) and, more specifically, MSH2 and MSH3 have been proposed to promote GAA repeat instability (Du et al., 2012; Ezzatizadeh et al., 2012; Halabi et al., 2012; Ku et al., 2010).

The repeat instability we observed therefore appears to be more similar to events arising in the somatic tissues of FRDA patients and distinct from the suggested instability in FRDA iPSCs resembling intergenerational expansion (Du et al., 2012; Ku et al., 2010).

75 The number of AGG interruptions and the length of uninterrupted CGG repeats at the 3' end are correlated with repeat instability on transmission, and their characterization may allow more accurate risk estimates of repeat instability and expansion to full mutations for intermediate and small premutation alleles.