Medically verified, diagnosed injuries would offer a more reliable endpoint.
A major improvement involved the use of a new case definition which included combinations of symptoms (see Table 1), thus providing a more reliable health endpoint termed "highly credible gastrointestinal illness" (HCGI).
Another candidate for the intermediate outcome is time to culture conversion, which is increasingly being used in phase II trials and is arguably a more reliable surrogate endpoint than culture status at a single time point [ 24].
We believe that operative reintervention for bleeding episodes represents a more reliable and clinically meaningful endpoint than bleeding episodes.
Sequence data was used to design new primers for more reliable detection of trh by endpoint PCR.
The advice of Ritting et al. [8] in a recent review was that instead of holding on to a fixed degree limit, the absence of a firm endpoint during testing is a more reliable criterion when clinically diagnosing a complete rupture of the UCL.
This conclusion, as highlighted also for the estimation of transmission endpoints in LF [5], signifies the need for collecting more reliable standardized data spanning the natural range of prevalences observed in the field at the regional level.
Together the results show that emotion-dependent amygdala habituation is a robust and considerably more reliable index than the mean amplitude, and provides a robust potential endpoint for within-subject designs including pharmaco-fMRI studies.
It is important to predefine the endpoints that should be collected during the study design phase since prospectively sampled information is more reliable and complete than information sampled retrospectively.
