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The new solid and dispersible pediatric FDCs offer ease of administration and more reliable dosing than crushing or multiple-splitting of adult FDCs.
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In order to obtain more reliable dose estimates for humans, the Helmholtz Zentrum München (HMGU) developed a new, physiologically more plausible biokinetic model [ 6].
The 3-D multicellular mES and HT-29 cultures could be used as more reliable models for assessing dose-dependent drug responses, potentially reducing or partially replacing animal experiments, and thus should have applications in the early-stage drug discovery as well as toxicological evaluation of chemical compounds.
At one time there was considerable optimism that BBDR models could provide more reliable estimates of low-dose risk.
The uncertainties in using colon dose call for considering the external (free-field) dose as probably a more reliable reference.
bContinued discussion of available routine immunization data in Nigeria determined that DTP coverage probably provides a more reliable estimate of routine immunization coverage for polio vaccine doses, because reported polio vaccine doses likely includes doses administered as part of SIAs.
Despite a range of gravimetric and chemical methods, there is a requirement to identify simpler and more reliable methods to quantify in vitro whole smoke dose, to support extrapolation and comparisons to human/in vivo dose.
Hence, we present a more reliable and efficient for providing the minimum dose path for occupational workers especially in complex radioactive environments with clutter obstacles and narrow areas.
There is a challenge today in assessing radiological dose from nuclear reactor using a more reliable computer tool in addressing the released radionuclide to the atmosphere and ground effectively and to compute the dose rates.
Furthermore, the choice of 0.3 IU/kg/day as a threshold for high-dose treatment is somewhat arbitrary; a larger sample size is needed for exploring more thoroughly the dose-response relationship, identifying a more reliable cutoff.
Comparison of the results demonstrated that the multiple dose (7×5) design led to a more reliable result than the OECD (4×10) design, despite the smaller total number of animals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com