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In order to obtain more reliable dose estimates for humans, the Helmholtz Zentrum München (HMGU) developed a new, physiologically more plausible biokinetic model [ 6].
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The new solid and dispersible pediatric FDCs offer ease of administration and more reliable dosing than crushing or multiple-splitting of adult FDCs.
The 3-D multicellular mES and HT-29 cultures could be used as more reliable models for assessing dose-dependent drug responses, potentially reducing or partially replacing animal experiments, and thus should have applications in the early-stage drug discovery as well as toxicological evaluation of chemical compounds.
At one time there was considerable optimism that BBDR models could provide more reliable estimates of low-dose risk.
The uncertainties in using colon dose call for considering the external (free-field) dose as probably a more reliable reference.
Despite a range of gravimetric and chemical methods, there is a requirement to identify simpler and more reliable methods to quantify in vitro whole smoke dose, to support extrapolation and comparisons to human/in vivo dose.
Hence, we present a more reliable and efficient for providing the minimum dose path for occupational workers especially in complex radioactive environments with clutter obstacles and narrow areas.
More pharmacokinetic data are required to establish reliable dose recommendations for ABCD in patients with liver failure.
bContinued discussion of available routine immunization data in Nigeria determined that DTP coverage probably provides a more reliable estimate of routine immunization coverage for polio vaccine doses, because reported polio vaccine doses likely includes doses administered as part of SIAs.
There is a challenge today in assessing radiological dose from nuclear reactor using a more reliable computer tool in addressing the released radionuclide to the atmosphere and ground effectively and to compute the dose rates.
Furthermore, the choice of 0.3 IU/kg/day as a threshold for high-dose treatment is somewhat arbitrary; a larger sample size is needed for exploring more thoroughly the dose-response relationship, identifying a more reliable cutoff.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com