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To determine the impact of the FVL mutation on pneumococcal pneumonia in a clinically more relevant setting we treated mice at 24 hours of pneumonia with ceftriaxone and sacrificed them another 24 hours later.
To ascertain that excessive Stat3 activation could mediate bleomycin-induced fibrosis independently of Smad3, we extended this observation to a physiologically more relevant setting where excessive Stat3 signalling occurred in gp130 wt mice in response to prolonged exposure to gp130 cytokines rather than through engagement of mutant gp130 757F receptors.
The current study adds to these earlier findings that APC is capable of inhibiting systemic and local coagulation during influenza-induced pneumonia and that this effect is present when APC administration is initiated 24 hours after infection, that is, in a clinically more relevant setting.
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We're reproducing tips from Economist.com's Cities Guide, in the hope that commentary from readers will enable us to establish a more relevant set of recommendations for the future.
which is probably the more relevant set of criticisms to which Morgan should have stuck.
While the regression-based predictors attempted to infer physical-chemical "rules" of binding preferences and, to this end, incorporated information from all available single-mutants, the average-based approach considered a smaller, but perhaps more relevant, set of single-mutants.
In the same vein, the comparison of highly context-dependent assays with biochemically oriented test batteries may help to identify more simplified cell-based assays and/or a more relevant set of biochemical endpoints for screening purposes.
It is now recognized that the more relevant clinical setting for cancer vaccines is in adjuvant setting in occult-disease patients.
"TTIP is perhaps more relevant as setting a precedent vis-a-vis third countries than governing trade and investment bilaterally," the paper says.
We envisioned use of this concept for monitoring drug-response in a more clinically relevant setting by using the CML model system.
In the last decade, in vivo models have complemented cell-line studies, giving a more physiologically relevant setting in which to understand the interrelationship of hypoxia and disease.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com